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OCR: R(b) Sera from patients with Graves' disease contain a mixture of TSH-R(s) and TSH- hese antibodies interacting with the TSH-R; t und titre, result of antibodies may have different affinities which may change spontaneously or as therapy. Changes in the titres of stimula responsible blocking antibodies to the TSH-R can be ting and e thyroid for fluctuating thyroid function where t es from state of the patient spontaneously chang vice versa. hypothyroidism to hyperthyroidism, or isible for R. 17.14). A similar mechanism may also be respo transient changes of thyroid function (F